广东11选5

血红蛋白和血红蛋白病的电泳

TONGCHANG,YOUXUEHONGDANBAI(Hb)GAIBIANYINQIDELINCHUANGZONGHEZHENGBEICHENGWEIXUEHONGDANBAIBING,BINGQIEJIZHONGSHIYANSHICESHIBEIJIESHIWEIZHIDAOTAMEN,QIZHONGZUIXIANGGUANDESHIHbDIANYONG(EF)。

广东11选5 RENHb 1FENZIYOU2DUIZHUDANBAILIANXINGCHENG,BINGQIEXUEHONGSUFENZIFUZHEYUTAMENZHONGDEMEIYIGE。ZAISHENGLIXUESHANG,XINGCHENG6ZHONGBIANTI:SANZHONGSHUNSHIPEITAIBIANTI,CHENGWEIHb Gower 1,Hb Gower 2HEHb Portland,HbF,QIZAITAIERSHENGMINGZHONGZHANZHUDAODIWEI,HbA,QIGOUCHENGCHENGRENHbHEHbA2DE95%YISHANG,YECUNZAIERTONGHECHENGRENDEBAIFENBIJIAODI(1-3.5%)。

广东11选5 YOUXUDUOHbBIANZHONGZAIYICHUANSHANGBEIQUEDING(YICHUAN),SUIRANDADUOSHUSHIWUHAIDE,DANQITABIANYIYINQILEXIANZHEDELINCHUANGBIANHUA。XUEHONGDANBAIBINGKEFENWEI3GEJIBENLEIBIE,ZUIXIANGGUANDESHIQIAN2GE:

  • Hb的结构变体,例如HbS(镰状细胞贫血症或镰状细胞病)。
  • 在产生1个或多个珠蛋白链时,默认合成足够量的正常Hb(地中海贫血)失败。
  • 在新生儿中发生正常跳跃导致HbF产生HbA失败(胎儿Hb的遗传性持续存在)。

DUIYISIXUEHONGDANBAIBINGHUANZHEDEDIAOCHAYINGBAOKUOYOUJIAZUSHI,TIGEJIANCHAHESHIYANSHIFENXIDEWANZHENGBINGSHI。ZHEIXIECESHIYIYU1975NIANYOUGUOJIXUEYEXUEBIAOZHUNHUAWEIYUANHUIDEZHUANJIAXIAOZUQUEDING:HONGSEXILIEJISHUYUZHISHU; XUEHONGDANBAI; FENXUEQI; WAIZHOUXUETUPIAN; WANGZHIHONGXIBAO; TIEDAIXIE; RONGJIEDUSHIYAN; falciformationCESHI; HbA2HEHbFDEDINGLIANG,YIJIHbZAIJIANXINGpHXIADEEF。RUGUOJIANCEDAODEHbBUWENDINGHUODUIYANGQIDEGAIBIANJUYOUQINHELI,ZEBIXUJIARUREWENDINGXING(TONGGUOJIARE)HEHUAXUE(YIBINGCHUN)SHIYAN。TONGGUOZHEIZHONGFANGSHI,ZAIDADUOSHUQINGKUANGXIAKEYIJINXINGKEKAODEZHENDUAN,JINGUANYOUSHIXUYAOCAIYONGGENGFUZADEJISHU,RUSUANXINGpHXIADEEF,QIUDANBAIDEYANJIU,

广东11选5 YISUANXIANWEISUZAIJIANXINGpHXIADEDIANYONG

广东11选5 ZHEIZHONGLEIXINGDEEFTONGCHANGSHIYONGCUSUANXIANWEISUMOZUOWEIJIZHIZAIpH8.4-8.6XIAJINXING,BINGQIESHIJIANDAN,KUAISUHELINGMINDEFANGFA。JIANCEZUICHANGJIANDEHbBIANTI,CHUANTONGSHANGSHIZUICHANGYONGDECHUSHIPINGGUJISHU。ZAIJIANXINGpHXIA,HbSHIDAIFUDIANHEDEDANBAIZHI,QIZAIDIANCHANGZHONGQIANYIDAOYANGJI(+)。BIAOMIANSHANGJUYOUBUTONGDIANHEDEHbBIANTIYUHbAFENLI,YINCI,SUOYOUJIANCEDAODEHbBIANTIDOUBUTONGYUHbA。HbKENENGSHIYICHANGDEERMEIYOUFUZAIDEBIANHUA,YINCITAMENJIANGBUHUIBEIQUFEN。LIYONGGAIJISHU,HUODEHbC,S,F,AHEJDEFENLI。JIANCEDAOBIANTISHI,LIANGHUABAIFENBIHENYOUYONG。

ZAICIFENXIZHONGKEYITICHUNAXIEJIESHIKUNNAN?

  • 可能难以检测诸如Hb Constant Spring,HbA2,Hb Bart和HbH之类的次要条带。
  • 在新生儿中,有少量HbA和大量HbF,很难检测出HbA。这就是为什么当没有检测到HbA时,你总是不得不在柠檬酸琼脂中使用EF,或者使用等电聚焦。
  • 不可能区分HbS,D和G.不可能区分HbC,E和O.因此,在HbS或C位置检测到单一条带的所有样品也应在柠檬酸琼脂中进行分析。或等电聚焦以排除复合杂合子如HbSD,SG,CE或CO的存在。